INSTRUCT training course: Advanced methods for the integration of diverse structural data, Florence IT

When:

Monday, February 19, 2018 - 12:30 to Friday, February 23, 2018 - 14:30

Description:

This Practical Course co-organized by INSTRUCT and West-Life will introduce and make extensive use of user-friendly e-Science portals to facilitate the adoption of the methods and techniques by the participants in their everyday work. In particular, we will exploit the web-based, cloud-enabled services of the WeNMR and West-Life e-infrastructures, also in collaboration with the European Grid Initiative (EGI). West-Life is a H2020 EU project.

The hands-on sessions will allow the students to try the methods on either pre-packaged or their own research data.

The course will address state-of-the-art tools and facilities.

Topics:

Model building in electron maps
Cryo-EM analysis of biomolecular assemblies
Comparison and integration of techniques
Data-driven docking
Information-driven docking
Design of small-molecule ligands
Bio-SAXS
MD refinement and simulations
SAXS and NMR methods for IDPs
Structure validation

Learning goal:

The Practical Course aims at training young researchers in the combined use of data from various structural techniques, such as SAXS, X-ray diffraction or EM, together with NMR data to achieve a deeper understanding of the structural properties of macromolecular systems, from individual proteins to macromolecular adducts. We will demonstrate various methods based on the integration of data from different structural techniques for the study of adducts between biological macromolecules, of protein-ligand interactions as well as of multi-domain proteins.

Contact(s):

Antonio Rosato

Venue:

University of Florence, Scientific Campus, Sesto Fiorentino, Florence – Italy

Address: