Course

Structural methods applicable to solutions facilitate structural and functional studies on biological macromolecules under close to native conditions. Fully exploiting this opportunity allows one to extract the maximum amount of biologically meaningful information and to relate the structural results to the function of the system. The main objective of this EMBO course is to train graduate students and postdocs in state-of-the-art methods to study biological macromolecules in solution. We aim at a comprehensive coverage of the major structural and biophysical techniques employed for characterization of high and low resolution structure and structural transitions, macromolecular complex formation, protein folding, stability, interactions and enzymatic mechanisms.

IT Service Management is a discipline that helps provide services with a focus on customer needs and in a professional manner. It is widely used in the commercial and public sectors to manage IT services of all types, but current solutions are very heavyweight with high barriers to entry.

FitSM is an open, lightweight standard for professionally managing services. It brings order and traceability to a complex area and provides simple, practical support in getting started with ITSM. FitSM training and certification provide crucial help in delivering services and improving their management. It provides a common conceptual and process model, sets out straightforward and realistic requirements and links them to supporting materials.

FitSM is the reference framework being used in several EOSC initiatives, among other research infrastructures as well. Through FitSM, the aim is to conduct effective IT service management in the EOSC federated environment and achieving a baseline level of ITSM that can act in support of ‘management interoperability’ in federated environments from EOSC related projects.  

In addition, participants have an opportunity to receive a formal certification backed by certification authority APMG for anyone successfully passing the exam (20 multiple choice questions, 13 required to pass). Both the costs of the training and the exam is covered and offered by the EOSC-hub project for free.

IT Service Management is a discipline that helps provide services with a focus on customer needs and in a professional manner. It is widely used in the commercial and public sectors to manage IT services of all types, but current solutions are very heavyweight with high barriers to entry.

FitSM is an open, lightweight standard for professionally managing services. It brings order and traceability to a complex area and provides simple, practical support in getting started with ITSM. FitSM training and certification provide crucial help in delivering services and improving their management. It provides a common conceptual and process model, sets out straightforward and realistic requirements and links them to supporting materials.

FitSM is the reference framework being used in several EOSC initiatives, among other research infrastructures as well. Through FitSM, the aim is to conduct effective IT service management in the EOSC federated environment and achieving a baseline level of ITSM that can act in support of ‘management interoperability’ in federated environments from EOSC related projects.  

In addition, participants have an opportunity to receive a formal certification backed by certification authority APMG for anyone successfully passing the exam (20 multiple choice questions, 13 required to pass). Both the costs of the training and the exam is covered and offered by the EOSC-hub project for free.

Il corso si svolgera' presso la Sala Venturi di INFN-CNAF Viale Berti Pichat 6/2, Bologna 

Saranno affrontati temi riguardanti la gestione di infrastrutture scalabili per l'analisi dei big data, partendo dal livello piu' basso (cloud e container e loro orchestrazione), proseguendo con le tecnologie di gestione dei dati (HDFS, Spark, Kafka), fino ad arrivare ai tool di analisi dati e all'applicazione di tecniche di Machine Learning per l'estrazione di nuove informazioni dai dati disponibili.  

Il corso avrà l'obiettivo di fornire dettagli su come istanziare in maniera automatizzata clusters per l'orchestrazione di container che implementano a loro volta un batch system a servizio. Verrà illustrato principalmente il caso di un sistema di batch basato su HTCondor, dando pero' esempi anche di piattaforme Spark per il training di Machine Learning.

Il corso fornirà gli strumenti di alto livello per l'utilizzo di infastrutture cloud finalizzato al processamento di dataset. In tal senso verranno mostrati strumenti per la gestione delle applicazioni (container), per la gestione del software (cvmfs) e dei dati (e.g. xrootd). Sarà inoltre mostrato concretamente l'esempio del workflow di data anlaisi dell’esperimento AMS, come pilota nell'utilizzo dei batch system a servizio.

Il corso si terrà presso la  Sezione INFN di Perugia, con inizio alle ore 14.00 del 25 Novembre e termine alle ore 13.00 circa del 28 Novembre 2019.

This is one-day Foundation level course provides an agnostic introduction to the basic IT service management concepts and terms, outlines the purpose and structure of FitSM standards and their relationship to other standards, and details the formal requirements defined within it.

IT Service Management is a discipline that helps provide services with a focus on customer needs and in a professional manner. It is widely used in the commercial and public sectors to manage IT services of all types, but current solutions are very heavyweight with high barriers to entry.

FitSM is an open, lightweight standard for professionally managing services. It brings order and traceability to a complex area and provides simple, practical support in getting started with ITSM. FitSM training and certification provide crucial help in delivering services and improving their management. It provides a common conceptual and process model, sets out straightforward and realistic requirements and links them to supporting materials.

FitSM is the reference framework being used in both EOSC-hub and EOSCpilot projects, among other research infrastructures as well. Through FitSM, the EOSC-hub project aims at conducting effective IT service management in a federated environment and achieving a baseline level of ITSM that can act in support of ‘management interoperability’ in federated environments where disparate organisations must cooperate to manage services. 

Structural biology, determining the three-dimensional shapes of biomacromolecules and their complexes, can tell us a lot about how these molecules function and the roles they play within a cell. Bioinformatics data derived from structure determination experiments enables life-science researchers to address a wide variety of questions. For example, it aids the understanding of how mutations in a gene might alter a protein’s shape, disrupt a catalytic site, or alter the binding affinity of a pharmaceutical compound.

This course explores bioinformatics data resources and tools for the interpretation and exploitation of biomacromolecular structures. It will focus on how best to analyse available structural data to gain useful information given specific research contexts. The course content will investigate the impact of genetic variation on structure, predicting protein structure and function, and exploring interactions with other macromolecules as well as with low-MW compounds. Participants will also have an opportunity to explore protein docking using HADDOCK

The fourth Course on Integrative Structural Biology, which will take place at the Institut Pasteur from july 8 to july 13, 2019

This course is supported by EMBO (European Molecular Biology Organization). For more information see here
Problems in structural biology today can very often not be solved by one technique alone, but need to be solved by a combination of methods, including NMR, X-ray crystallography, electron microscopy, structural mass spectrometry, and SAXS. The heterogeneous data coming from these methods need to be combined with advanced molecular modeling techniques. The goal of the course is to provide young scientists that have more specialized knowledge in one of the techniques an overview over the broad range of modern structural methods available. Special emphasis will be given to computational approaches to integrate data (such as IMP, ARIA).